{"id":9999,"date":"2026-10-19T12:10:29","date_gmt":"2026-10-19T12:10:29","guid":{"rendered":"https:\/\/www.bgene.fr\/?p=9999"},"modified":"2026-10-19T12:15:09","modified_gmt":"2026-10-19T12:15:09","slug":"bgene-ouvre-insili4bio-aux-partenariats-la-plateforme-numerique-qui-accelere-vos-projets-de-bioproduction","status":"publish","type":"post","link":"https:\/\/www.bgene.fr\/en\/bgene-ouvre-insili4bio-aux-partenariats-la-plateforme-numerique-qui-accelere-vos-projets-de-bioproduction\/","title":{"rendered":"BGene ouvre InSili4Bio aux partenariats\u00a0: la plateforme num\u00e9rique qui acc\u00e9l\u00e8re vos projets de bioproduction"},"content":{"rendered":"

BGene Genetics annonce l’ouverture aux partenariats et prestations de service de InSili4Bio<\/strong>, sa suite d’outils bioinformatiques propri\u00e9taires d\u00e9di\u00e9e \u00e0 la conception rationnelle en biocatalyse et en bioproduction.<\/p>\n\n\n\n

D\u00e9velopp\u00e9e en interne au fil de nos projets R&D, InSili4Bio rassemble des modules couvrant l’ensemble des processus de conception : identification des voies m\u00e9taboliques, ing\u00e9nierie enzymatique et m\u00e9tabolique, choix rationnel du ch\u00e2ssis de production et des enzymes, et optimisation des souches. La plateforme r\u00e9pond \u00e0 des verrous techniques concrets : faible efficacit\u00e9 catalytique limitant le passage \u00e0 l’\u00e9chelle, g\u00e9n\u00e9ration de co-produits ind\u00e9sirables, solubilit\u00e9 insuffisante en milieu aqueux, tout en combinant mod\u00e9lisation in silico<\/em> et validation exp\u00e9rimentale au laboratoire.<\/p>\n\n\n\n

InSili4Bio a d\u00e9j\u00e0 fait ses preuves en conditions r\u00e9elles. Sur une famille d’enzymes reconnues pour leur faible activit\u00e9, l\u2019identification in silico<\/em> d’une mutation cibl\u00e9e a permis de multiplier par 10 l’activit\u00e9 enzymatique et d’atteindre des titres de bioproduction parmi les plus \u00e9lev\u00e9s du march\u00e9. Une exploration in silico<\/em> de la diversit\u00e9 enzymatique a conduit \u00e0 l\u2019identification d\u2019une enzyme 100% sp\u00e9cifique d\u2019un substrat. Cette d\u00e9couverte a am\u00e9lior\u00e9 significativement l\u2019efficacit\u00e9 de la r\u00e9action tout en emp\u00eachant la formation de co-produits.<\/p>\n\n\n\n

Ce savoir-faire \u00ab drylab \u00bb, coupl\u00e9 \u00e0 notre expertise \u00ab wetlab \u00bb, a aliment\u00e9 le d\u00e9p\u00f4t de 11 familles de brevets<\/strong>, aujourd’hui disponibles sous licence.<\/p>\n\n\n\n

Afin de participer \u00e0 une industrie plus durable et plus ind\u00e9pendante des \u00e9nergies fossile, nous mettons d\u00e9sormais InSili4Bio et nos \u00e9quipes \u00e0 disposition des entreprises qui souhaitent acc\u00e9l\u00e9rer leurs projets en cosm\u00e9tique, ar\u00f4mes & parfums, nutraceutique ou chimie verte \u00e0 la fois en prestation de service ou en co-d\u00e9veloppement.<\/p>\n\n\n\n

Vous avez un d\u00e9fi de biocatalyse ou de bioproduction ? Parlons-en<\/em><\/p>\n\n\n\n

\n
Contact us<\/a><\/div>\n<\/div>\n\n\n\n

BGene opens InSili4Bio to partnerships: the digital platform that accelerates your bioproduction projects<\/strong><\/h2>\n\n\n\n

BGene opens InSili4Bio to partnerships: the digital platform that accelerates your bioproduction projects BGene Genetics announces the opening to partnerships and services of InSili4Bio<\/strong>, its suite of proprietary bioinformatics tools dedicated to rational design in biocatalysis and bioproduction.<\/p>\n\n\n\n

Developed in-house over the course of our R&D projects, InSili4Bio brings together modules covering all design processes: identification of metabolic pathways, enzymatic and metabolic engineering, rational choice of production chassis and enzymes, and optimization of strains. The platform addresses concrete technical barriers: low catalytic efficiency limiting scale-up, generation of undesirable co-products, insufficient solubility in aqueous media, while combining in silico<\/em> modeling and experimental validation in the laboratory.<\/p>\n\n\n\n

InSili4Bio has already proven itself in real condition. On a family of enzymes known for their low activity, the in silico<\/em> identification of a targeted mutation has made it possible to multiply the enzymatic activity by 10 and to achieve some of the highest bioproduction titers on the market. An in silico<\/em> exploration of the enzymatic diversity led to the identification of an enzyme that is 100% substrate specific. This discovery significantly improved the efficiency of the reaction while preventing the formation of co-products.<\/p>\n\n\n\n

This \u00ab\u00a0drylab\u00a0\u00bb know-how, coupled with our \u00ab\u00a0wetlab\u00a0\u00bb expertise, has fueled the filing of 11 patent families<\/strong>, which are now available under license.<\/p>\n\n\n\n

To participate in a more sustainable and fossil fuel-independent industry, we now make InSili4Bio and our teams available to companies that wish to accelerate their projects in cosmetics, flavors & fragrances, nutraceuticals or green chemistry both in terms of service provision and co-development.<\/p>\n\n\n\n

Do you have a biocatalysis or bioproduction challenge? Let’s talk.<\/p>\n\n\n\n

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Contact us<\/a><\/div>\n<\/div>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

BGene Genetics annonce l’ouverture aux partenariats et prestations de service de InSili4Bio, sa suite d’outils bioinformatiques propri\u00e9taires d\u00e9di\u00e9e \u00e0 la conception rationnelle en biocatalyse et en bioproduction. D\u00e9velopp\u00e9e en interne au fil de nos projets R&D, InSili4Bio rassemble des modules couvrant l’ensemble des processus de conception : identification des voies m\u00e9taboliques, ing\u00e9nierie enzymatique et m\u00e9tabolique, […]<\/p>\n","protected":false},"author":28,"featured_media":8816,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-9999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/posts\/9999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/comments?post=9999"}],"version-history":[{"count":3,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/posts\/9999\/revisions"}],"predecessor-version":[{"id":10003,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/posts\/9999\/revisions\/10003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/media\/8816"}],"wp:attachment":[{"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/media?parent=9999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/categories?post=9999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bgene.fr\/en\/wp-json\/wp\/v2\/tags?post=9999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}